Programme
(Download the Book of Abstracts here.)
October 2, Thursday
- 08:30-09:00: Registration of participants
- 09:00-09:30: Peter Kolb (GLISTEN Chair): Update about recent developments and plans
- 09:30-10:15: Matthew Todd (University of Sydney, UK): Open Source Approaches to Discovery in Medicinal Chemistry
- 10:15-10:45: Zafiroula Georgoussi (National Centre for Scientific Research, GR): WG3: OPIOID RECEPTOR SIGNALING MECHANISMS: BEYOND THE G PROTEIN PARADIGM
- 10:45-11:15: Coffee break
- 11:15-11:45: Mickey Kosloff (University of Haifa, IL): WG3: Deciphering and re-designing interaction specificity in G-protein signaling
- 11:45-12:00: Martha E. Sommer (Charité - Universitätsmedizin Berlin, DE): WG3: FORMATION OF THE ARRESTIN-GPCR COMPLEX: A TALE OF TWO LOOPS
- 12:00-12:15: Rosana Inácio dos Reis (Oxford University, UK): WG3: FORMATION, PURIFICATION AND CHARACTERIZATION OF A PHARMACOLOGICALLY RELEVANT AND FUNCTIONALLY COMPETENT b2 ADRENERGIC RECEPTOR-βARRESTIN COMPLEX
- 12:15-12:30: Stefan Mordalski (Institute of Pharmacology PAS, PL): WG3: COMPUTATIONAL STUDY ON GPCR – G PROTEIN INTERFACES
- 12:30-12:45: Chayne Piscitelli (Paul Scherrer Institute, CH): WG3: STRUCTURAL STUDIES OF GPCRS
- 12:45-13:00: Patricia M. Dijkman (University of Oxford, UK): WG3: DYNAMIC GPCR DIMERISATION SHOWN BY ENSEMBLE AND SINGLE MOLECULE FRET, AND DEER
- 13:00-14:00: Lunch and poster session
- 14:00-16:00: MC meeting
- 14:00-15:20: Training school
- Topics: GPCR pharmacology and fragment screening on GPCRs (András Visegrády, Rob Leurs/Hans Bräuner-Osborne)
- 16:00-16:45: Rob Leurs (VU University Amsterdam, NL): WG2: GPCR-ligand binding kinetics
- 16:45-17:20: Daniel Fourmy (University of Toulouse, FR): WG2: Characterization of internalization of the human GIP receptor enables discovery of a biased agonist
- 17:20-17:50: Coffee break
- 17:50-18:25: Jean-Yves Springael (Université Libre de Bruxelles, BE): WG2: BIASED SIGNALING AT CHEMOKINE RECEPTORS DOES NOT FOLLOW THE G-PROTEIN VERSUS β-ARRESTIN PARADIGM
- 18:25-19:00: Dietmar Weichert (Friedrich-Alexander University Erlangen-Nuremberg, DE): WG2: PROBING A MOLECULAR DETERMINANT FOR BIASED AGONISM AT THE ß2-ADRENOCEPTOR
- 20:00: Thermal bath (rudasfurdo.hu)
October 3, Friday
- 09:00-09:45: Jan Steyaert (Vrije Universiteit Brussel, BE): Nanobody-enabled fragment screening on active-state constrained GPCRs
- 09:45-10:15: Holger Stark (Heinrich-Heine-Universitaet, DE): WG4: NOVEL AGONISTS FOR THE DOPAMINE D3 RECEPTOR SUBTYPE WITH HIGH IN VIVO ACTIVITY
- 10:15-10:45: Dominique Bonnet (University of Strasbourg, FR): WG4: Fluorescent probes to track GPCR binding and dimerization
- 10:45-11:20: Coffee break
- 11:20-11:30: Katarzyna Kieć-Kononowicz (Jagiellonian University, PL): WG4: ANNELATED XANTHINES AS A1/A2A/A2B ADENOSINE RECEPTORS LIGANDS
- 11:30-11:40: Annika Kreuchwig (Leibniz-Institut für Molekular Pharmakologie (FMP), DE): WG4: GPCR-SSFE, A PLATTFORM FOR AUTOMATIC MULTIPLE-TEMPLATE BASED HOMOLOGY MODELING OF GPCRs
- 11:40-11:50: Jhonny Azuaje (University of Santiago de Compostela, ES): WG4: UGI-BASED ENGINEERING PROVIDES CONVERGENT ASSEMBLY AND NOVEL ARCHITECTURES FOR HOMOBIVALENT LIGANDS
- 11:50-12:00: Juan Carlos Mobarec (University of Marburg, DE): WG4: IN-SILICO TARGETING OF OBESITY: THE CASE OF THE HUMAN BILE ACID RECEPTOR
- 12:00-12:10: Marie Chabbert (CNRS - INSERM, FR): WG4: EVOLUTIONARY HUBS IN SELECTED GPCR FAMILIES
- 12:10-12:40: Esther Kellenberger (Université de Strasbourg, FR): WG4: GLISTENDB presentation
- 12:40-14:30: Lunch and poster session
- 13:30-14:30: Public GPCRDB Demo of new features
- 14:30-15:15: Francesca Magnani (University of Pavia, IT): WG1: Tuning of Ligand Selectivity to GPCR Subtypes by electronic sculpting
- 15:15-16:00: Dmitry Veprintsev (Paul Scherrer Institut and ETH Zurich, CH): WG1: PROTEIN BACKBONE NMR REVEALS LIGAND RECOGNITION, SIGNAL TRANSMISSION, AND QUENCHING OF MOTIONS BY THERMOSTABILIZATION IN THE β1-ADRENERGIC RECEPTOR
- 16:00-16:30: Coffee break
- 16:30-16:50: Bruck Taddese (CNRS-French National Centre for Scientific Research, FR): WG1: Correlated motions in distinctive conformational states of the chemokine receptor CXCR4
- 16:50-17:10: Luc Veya (EPFL, CH): WG1: SINGLE-MOLECULE MICROSCOPY DECIPHERS THE RELATION BETWEEN TRAFFICKING AND SIGNALING OF THE NK1 RECEPTOR IN LIVING CELLS
- 17:10-17:30: Mauricio Esguerra (Uppsala University, SE): WG1: New features for GPCR modeling implemented on GPCR-MODSYM and PYMEMDYN
- 17:30-19:30: Training school
- Topics: Fragment docking and virtual screening on GPCRs (Márton Vass and Chris de Graaf)
- 20:00: Conference dinner
October 4, Saturday
- 09:00-13:00: GPCRDB Satellite Meeting (parallel with Training school)
- 09:00-11:00: David Gloriam (University of Copenhagen, DK): Introduction and server/mutagenesis committees
- 11:00-11:30: Coffee break
- 11:30-13:00: David Gloriam (University of Copenhagen, DK): Joint discussion, applications & publications
- Register by email to david.gloriam@sund.ku.dk
- 09:00-13:00: Training school
- 09:00-11:00: Fragment optimizations (Greg Makara and György Ferenczy)
- 11:00-11:30: Coffee break
- 11:30-13:00: Synthesis lectures (Tibor Soós)
- 13:00-14:30: Lunch
- 14:30-18:00: Training school
- 14:30-16:00 Retrosynthesis (Maikel Wijtmans)
- 16:00-16:30: Coffee break
- 16:30-18:00 Reaxys tutorial (Maikel Wijtmans)